Fig. 4.
After intravenous (IV) injection of acetazolamide (AZ) in anesthetized rabbit, effect on brain surface extracellular fluid (ECF) hydrogen ion (H+) when partial pressure of extracellular fluid carbon dioxide (ECF PCO2) is held constant by increasing ventilation. ECF pH decreased 0.08 (recorded as hydrogen ion in nM) with accumulation of carbonic acid. Paco2 decreased 8 mmHg. Previous studies showed that tissue Po2 rose, excluding a hypoxic lactic acidosis. CO2 = carbon dioxide; PET = end-tidal partial pressure. Reprinted with permission from J Appl Physiol 1988; 65:422–7.