Nationally estimated number of prescriptions dispensed for available ADF opioids from U.S. outpatient retail pharmacies, 2012–2016. Source: Quintiles IMS, National Prescription Audit. Data abstracted by the FDA. Reprinted with permission from FDA Briefing Document, Joint Meeting of Anesthetic and Analgesic Drug Products Advisory Committee and Drug Safety and Risk Management Advisory Committee, July 26, 2017. Available at: https://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/AnestheticAndAnalgesicDrugProductsAdvisoryCommittee/UCM568075.pdf. Accessed December 1, 2017. ADF = abuse-deterrent opioid formulation; ER = extended release; FDA = Food and Drug Administration; IR = immediate release; SI = single ingredient.