Fig. 4.
Pyrrolidinedithiocarbamate (PDTC) inhibited nuclear transcription factor κB (NF-κB) nuclear translocation and reduced the increase in N-Myc downstream-regulated gene–2 (NDRG2) and proinflammatory cytokine expression induced by oxygen-glucose deprivation/reoxygenation (OGD/R). (A) Oxygen-glucose deprivation (OGD) induced the nuclear translocation of NF-κB, and PDTC pretreatment significantly inhibited this nuclear translocation. (B) PDTC markedly reduced the increase in NDRG2 expression induced by OGD/R. The data are expressed as the mean ± SD (n = 6). *P < 0.05 versus the control (Con) group, and #P < 0.05 versus the OGD/R + vehicle group. (C and D) PDTC markedly reduced the OGD/R-induced increase in proinflammatory cytokine (TNF-α and IL-6) secretion by primary astrocytes. The data are expressed as the mean ± SD (n = 6). *P < 0.05 versus the Con group, and #P < 0.05 versus the OGD/R + vehicle group.