Fig. 5.
Dasatinib does not affect psychomotor stimulation by morphine. (A) Graph of locomotion averaged over 3 days of conditioning with dasatinib and/or morphine. Dasatinib had no effect on locomotion when administered alone to wild-type mice (n = 8). Dasatinib (n = 8) also had no effect compared with vehicle (n = 8) on the stimulation of locomotion by morphine, which was significant in both cases (*P < 0.001, paired t test). (B) Dasatinib (5 mg/kg) was without effect on distance traveled by mice (n = 8) on all 3 days of conditioning. (C) Morphine caused locomotor stimulation with sensitization over the 3 days of conditioning when mice were administered either vehicle (left panel) or dasatinib (right panel) intraperitoneally (*P < 0.0001, two-way ANOVA, post hoc Bonferroni test).