Figure 1. Effects of 60 micro Meter etomidate (A), propofol (B), and midazolam (C) on inward Calcium2+ channel current (ICa) elicited by depolarizing pulse from a holding potential (HP) of -40 to 0 mV in three ventricular cells (upper), and corresponding current-voltage relationships (lower). The control current-voltage relationship for activation of ICa(expressed as a fraction of control maximal ICa) was reduced by all three anesthetics. *P less or equal to 0.05 versus anesthetic. Concentration-dependent decrease of the peak ICaamplitude (expressed as a percentage of control) by 5, 30, and 60 micro Meter etomidate, propofol, and midazolam in a total of 64 canine ventricular cells is shown in panel D. *P less or equal to 0.05 versus control; (dagger)P less or equal to 0.05 versus etomidate; (section)P less or equal to 0.05 midazolam versus propofol.