Figure 2.19F Nuclear magnetic resonance (NMR) analysis of metabolites of compound A in human urine after anesthetization with sevoflurane. Humans were anesthetized with sevoflurane, and urine samples were analyzed as described in Materials and Methods. (A)19F NMR spectrum of urine from a person before anesthetization with sevoflurane. (B)19F NMR spectrum of urine from a person anesthetized with sevoflurane. (C)19F NMR spectrum of urine recorded after addition of synthetic compounds 11 and 12 to the sample shown in B. The19F NMR spectra shown in A, B3, and C are typical of the spectra recorded in 13 participants.