American Society of Anesthesiologists

$Figure 2. (A) The effect of statistical inaccuracy in estimating specificity over a fractional range of 0.892–0.965, representing the 95% confidence interval for the European MH Group (EMHG) in vitro contracture test (IVCT). Positive predictive value is affected slightly but retains an elbow near the pretest probability (PTP) of 0.125–0.25. (B) Inaccuracy, within the 95% confidence interval for IVCT, in estimating sensitivity has a profound effect on negative predictive value (NPV) at high PTPs. A sharp elbow exists at PTPs near 0.8, with NPV decreasing at high PTPs.$

Figure 2. (A) The effect of statistical inaccuracy in estimating specificity over a fractional range of 0.892–0.965, representing the 95% confidence interval for the European MH Group (EMHG) in vitro contracture test (IVCT). Positive predictive value is affected slightly but retains an elbow near the pretest probability (PTP) of 0.125–0.25. (B) Inaccuracy, within the 95% confidence interval for IVCT, in estimating sensitivity has a profound effect on negative predictive value (NPV) at high PTPs. A sharp elbow exists at PTPs near 0.8, with NPV decreasing at high PTPs.

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