Figure 6. Concentration-effect curve for propofol inhibition of Ca2+-dependent veratridine-evoked glutamate release from synaptosomes. Synaptosomes were preincubated with 1.3 mM CaCl2and glutamate release was evoked by veratridine (20 micro Meter, open circles; 60 micro Meter, closed circles). Data are shown as means + SEM (n = 3–13). The corresponding concentrations of free propofol shown in the lower scale were determined by high-pressure liquid chromatography after equilibrium dialysis. *P < 0.05 versus control (no propofol) by analysis of variance followed by Fisher's post hoc test.