Figure 8. Effect-site model. The kinetic model consisted of a three-compartment model with the compartments with volumes V1, V2, V3, and clearances C11, C12, and C13. By adding an effect compartment (E), which is connected with the central compartment through a rate constant k1e, which has an elimination rate constant of ke0, the equilibration delay between central compartment and effect compartment is described by ke0.