Figure 2. Dose-response effects of alphaxalone (0.75 and 1.5 mg/kg) pretreatment in the formalin test (A). Preinjury treatment compared with postinjury treatment of vehicle versus 1.5 mg/kg alphaxalone (B). Vehicle and 1.5 mg/kg alphaxalone compared with the combined administration of alphaxalone and 0.25 mg/kg picrotoxin (C). Preinjury versus postinjury 0.25 mg/kg picrotoxin when administered with either vehicle or alphaxalone (D). ((section) ALX 1.5 PRE was different from CREM PRE, * ALX 1.5 PRE was different from ALX 1.5 POST or ALX/PIC/for, approximately CREM POST was different from CREM PRE, P < 0.05, Newman-Keuls post hoc comparison.)