Fig. 4.
Maximum changes in mean arterial pressure (MAP) and heart rate (HR) ±SD after large doses of CW002 (0.2 to 2.4 mg/kg) or approximately 5 to 60 × effective dose producing 95% block of twitch (ED95) given to Rhesus monkeys under isoflurane. “First dose of the day” bolus (red) versus cumulative (incremental) administration (blue). Change in MAP was significantly different from baseline at 0.8 and 1.60 mg/kg after first bolus doses (P = 0.049 and 0.001); change in HR was not significant after bolus doses of 0.08 or 1.60 mg/kg. Neither change in HR nor MAP was significantly different from baseline at any other point/dose after either bolus or cumulative administration, possibly due to small sample sizes (n = only 3 studied at bolus dose of 2.4 mg/kg; see included table of P values). The major observation is the trend toward ↑ HR and ↓ MAP seen in the case of bolus administration versus the trend toward decrease in both MAP and HR in the case of cumulative administration. See Discussion, Bolus versus Cumulative Administration: Circulatory Consequences Are Different, for further details. The table at the bottom of this figure shows P values for all comparisons.