Fig. 7.
Flumazenil can act as a competitive antagonist at high γ-aminobutyric acid receptor type A (GABA) concentrations. (A) Representative traces of GABA-evoked chloride currents in the presence and absence of 4 μM flumazenil. Black traces are GABA alone and orange traces are coapplication of GABA and flumazenil. (B) Summative dose–response curves for application of GABA and GABA plus flumazenil to α1β2γ2s receptors (n = 8 cells). Error bars represent SEM. DMSO = dimethyl sulfoxide; DRC = dose–response curve.

Flumazenil can act as a competitive antagonist at high γ-aminobutyric acid receptor type A (GABA) concentrations. (A) Representative traces of GABA-evoked chloride currents in the presence and absence of 4 μM flumazenil. Black traces are GABA alone and orange traces are coapplication of GABA and flumazenil. (B) Summative dose–response curves for application of GABA and GABA plus flumazenil to α1β2γ2s receptors (n = 8 cells). Error bars represent SEM. DMSO = dimethyl sulfoxide; DRC = dose–response curve.

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