Flumazenil (FLZ) hastens electroencephalography (EEG) markers of emergence from isoflurane. Box plots reflecting median, quartiles, and range are shown for EEG wake, eye blink, and ambulation in animals treated with saline (SAL; indicated in blue; n = 14) versus FLZ (FLZ is indicated in orange; n = 12) at the cessation of anesthesia. *P = 0.042; area under the receiver-operating characteristic curve (AUC): 0.74 (0.55 to 0.93) using Mann–Whitney U test and AUC.