The reaction of individual measures to clinical and experimental stimuli. Nociception level (NoL) changed with statistical significance after all noxious stimuli and remained unchanged during nonnoxious period. Heart rate (HR) changed with statistical significance after intubation only. Note the opposite from expected direction of change in surgical pleth index (SPI) and pulse plethysmograph amplitude (PPGA) after 1st tetanic stimulus (TET1). Note stable state entropy (SE) at all points reflecting adequate sedation. Wilcoxon signed-rank test. *P < 0.00625, **P < 0.001, ***P < 0.0001. $Significant reaction opposite to expected direction. For each box: central mark = median; edges of box = 25, 75 percentiles; whiskers extend to the most extreme data points; outliers are plotted individually by +. post = poststimulus; pre = prestimulus TET2 = second tetanic stimulus; TNP = nonnoxious period; TP1 = intubation; TP2 = skin incision/first trocar insertion.