Nebulized JM25-1 reduces airway remodeling caused by allergen-induced lung inflammation in mice. Quantitative assessment of mucus production (A) and fibrotic changes (B) was carried out in lung sections by morphometric analyses. All histologic examinations were undertaken 24 h after the last ovalbumin (OVA) challenge. Ovalbumin-challenged mice were treated by exposure to an aerosol of JM25-1 (0.25 to 1%), and all samples for histologic examinations were obtained 24 h after the last ovalbumin challenge. Data are expressed as mean ± SD (n = 7 for all groups). §P < 0.001 versus saline group, ***P < 0.001 versus ovalbumin-challenged group, one-way ANOVA followed by the Student–Newman–Keuls test. PAS = periodic acid–Schiff.