Fig. 2.
Thromboelastometry parameters. Extrinsically activated thromboelastometric test (activator: tissue factor) (EXTEM) and intrinsically activated thromboelastometric test (activator: ellagic acid) (INTEM) were performed according to the manufacturer’s instructions. Clotting time (CT; A and B) represents the initiation of clot formation. Clot formation time (CFT; C and D) represents the time between clot initiation and attainment of an amplitude of 20 mm; EXTEM CFT was not measurable in controls at 120 min posttrauma. Maximum clot firmness (MCF; E and F) reflects the strength of the clot that is formed. Data are shown as mean ± SD; n = 8 for each data point except “all animals,” n = 32; control group (120 min posttrauma), n = 3; PCC25 group (120 min posttrauma), n = 5; and PCC25 group (180 min posttrauma), n = 4. BL = baseline; HD = high dabigatran (after infusion); LD = low dabigatran (after oral administration); PCC = prothrombin complex concentrate. *P < 0.05 versus PCC50 and PCC100; †P < 0.05 versus PCC100; ‡P < 0.05 versus all PCC doses.