Tranexamic acid (TXA) plasma concentration measured after administration of different dose schemes in adults and pediatrics. High dose: 30 mg/kg loading dose, 2 mg/kg in cardiopulmonary bypass (CPB), and 16 mg kg⁻¹ h⁻¹. Low dose: 10 mg/kg loading dose, 1 mg/kg in CPB, and 1 mg kg⁻¹ h⁻¹. Continuous: 10 mg/kg loading dose, 10 mg/kg in CPB, and 1 mg kg⁻¹ h⁻¹. Discontinuous: 10 mg/kg loading dose, 10 mg/kg in CPB, and 10 mg/kg at the end of CPB.