Fig. 2.
Rosiglitazone (rosi) attenuated mechanical hyperalgesia in combination with resolvin D1 (RvD1) in db/db mice. (A) Withdrawal threshold to mechanical stimuli. Two-way ANOVA (interaction factor: F36,390 = 7.95, P < 0.0001) followed by separate one-way ANOVA with Tukey post hoc test for comparing the mean withdrawal threshold at each time (before: F9,78 =10.60, P < 0.0001; day 2: F9,78 = 1.647, P = 0.1165; day 3: F9,78 = 2.978, P = 0.0042; day 4: F9,78 = 13.77, P < 0.0001; and day 7: F9,78 = 21.80, P < 0.0001). (B) Withdrawal latency to thermal stimuli. Two-way ANOVA (interaction factor: F36,390 = 0.6565, P = 0.9383). (C) Paw edema after incision. Two-way ANOVA (interaction factor: F36,390 = 2.377, P < 0.0001) followed by separate one-way ANOVA with Tukey post hoc test for comparing the mean paw thickness at each time (before: F9,78 = 3.976, P = 0.0003; day 2: F9,78 = 11.15, P < 0.0001; day 3: F9,78 = 10.14, P < 0.0001; day 4: F9,78 = 10.07, P < 0.0001; and day 7: F9,78 = 7.618, P < 0.0001). The results are presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. DMSO = dimethyl sulfoxide.