Fig. 8.
Expressions of spinal proinflammatory cytokines and chemokines after blockade or knockout of ST2 in spared nerve injury (SNI) mice. (A) Bio-Plex showing the expressions of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and CCL2 5 h after a single intrathecal administration of the ST2 antibody (300 ng) on the 7th day after SNI. *P < 0.05, **P < 0.01 compared with the naive group. #P < 0.01 compared with the SNI + IgG group; n = 5 mice for each group. (B) Results of the Bio-Plex analysis of the spinal IL-1β, IL-6, TNF-α, and CCL2 levels of the 7th day after SNI in the ST2−/− mice and wild-type (WT) mice. *P < 0.05, **P < 0.001 compared with the WT naive group. #P < 0.01 compared with the WT SNI group; n = 5 mice for each group. All data are shown as the mean ± SEM.

Expressions of spinal proinflammatory cytokines and chemokines after blockade or knockout of ST2 in spared nerve injury (SNI) mice. (A) Bio-Plex showing the expressions of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and CCL2 5 h after a single intrathecal administration of the ST2 antibody (300 ng) on the 7th day after SNI. *P < 0.05, **P < 0.01 compared with the naive group. #P < 0.01 compared with the SNI + IgG group; n = 5 mice for each group. (B) Results of the Bio-Plex analysis of the spinal IL-1β, IL-6, TNF-α, and CCL2 levels of the 7th day after SNI in the ST2−/− mice and wild-type (WT) mice. *P < 0.05, **P < 0.001 compared with the WT naive group. #P < 0.01 compared with the WT SNI group; n = 5 mice for each group. All data are shown as the mean ± SEM.

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