Figure 5. Model predictions of arterial plasma concentrations after intravenous thiopental administration, 250 mg, in one min. A, Cardiac output (CO). Blood flows are increased or decreased 50% relative to the standard human, or altered dynamically to produce a 20% thiopental-induced decrease in cardiac output. The inset displays the predictions over 60 min. B, Obesity. Organ masses are increased or decreased relative to the standard human. The “lean” human is 15% underweight. OW denotes overweight. The inset displays the predictions over 120 min. C, Gender. Blood flows and body compositions are changed for females or males. D, Age. Blood flows and body compositions are changed for subjects of age 35, 70, and 90 yr.