American Society of Anesthesiologists

$Figure 2. Inhibition of ICa,L by four concentrations of bupivacaine. Ordinates are fractions of peak ICa,L (i.e., ICa,l /ICa,L control) after correction for rundown, which did not exceed 0.012 nA/min. Currents were evoked as in Figure 1(A). Five minutes of control (open circles) was followed by 5 min of bupivacaine (filled circles, onset at upward arrow), and 5 min of wash (open circles, onset at downward arrow). N = 6 (10 micro Meter), 5 (30 micro Meter), 5 (100 micro Meter), and 6 (300 micro Meter) myocytes. SEM bars were not shown (see Figure 3for SEM bars).$

Figure 2. Inhibition of I^Ca,L by four concentrations of bupivacaine. Ordinates are fractions of peak I^Ca,L (i.e., I^Ca,l /I^Ca,L control) after correction for rundown, which did not exceed 0.012 nA/min. Currents were evoked as in Figure 1(A). Five minutes of control (open circles) was followed by 5 min of bupivacaine (filled circles, onset at upward arrow), and 5 min of wash (open circles, onset at downward arrow). N = 6 (10 micro Meter), 5 (30 micro Meter), 5 (100 micro Meter), and 6 (300 micro Meter) myocytes. SEM bars were not shown (see Figure 3for SEM bars).

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