Figure 1. Effect of anesthesia and xanthine oxidase inactivation on alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) activity release and circulating lactate after aortic occlusion-reperfusion. Groups were fentanyl plus droperidol anesthesia, aortic occlusion-reperfusion (black circles, F&D); halothane anesthesia, aortic occlusion-reperfusion (black triangles, halothane); fentanyl plus droperidol anesthesia, aortic occlusion-reperfusion, sodium tungstate diet (open circles, F&D, T); and halothane anesthesia, aortic occlusion-reperfusion, sodium tungstate diet (open triangles, halothane, T). Halothane anesthesia significantly increased circulating ALT, AST, and LDH activity and lactate concentration compared with fentanyl plus droperidol anesthesia after aortic occlusion-reperfusion (*P < 0.05). Inactivation of xanthine oxidase activity with sodium tungstate significantly decreased circulating ALT, AST, and LDH activity and lactate concentration activity after aortic occlusion-reperfusion in halothane-anesthetized animals ([dagger]P < 0.05). Only the occlusion-reperfusion groups are depicted in the figure. Values for the matched sham-operated groups are shown in Table 1. Values are mean +/- SD.