Fig. 2.
Effects on pain behaviors of oral eplerenone (EPL) (100 mg kg−1 day−1) given starting 7 days after local dorsal root ganglion inflammation (LID) surgery and continuing to the end of the experiment (day 14). (A) Eplerenone had an effect on already-established mechanical hypersensitivity starting at day 8. Eplerenone effects on response to light brush strokes (B) and acetone (cold test) (C) are also shown. N = 9 animals per group. *P < 0.05; **P < 0.01; ***P < 0.001, significant difference between the two groups on the indicated day (two-way repeated-measures ANOVA with Bonferroni post-test). PWT = paw withdrawal threshold.