Kaplan-Meier plot for adverse cardiac events during 1 yr of follow-up stratified to the wild type (WT) or the variant (heterozygous and mutant) of the β₁-adrenergic receptor polymorphism Arg389Gly. Eachcurverepresents the cumulative percentage of patients remaining event free. There is a significant difference in event-free survival in patients with the wild-type genotype compared with patients with the variant (81.3%vs.67.6%, Mantel-Cox log rank test; P = 0.034). Ninety-five percent confidence intervals are shown at 3, 6, 9, and 12 months.