Fig. 3.
Complete blockade of Ca2+ transient by combined administration of selective ICa subtype blockers. Application of T-type blocker mibefradil (Mib, 200 nm), L-type blocker nitrendipine (Nit, 10 μm), N-type blocker SNX-111 (200 nm), P/Q-type blocker ω-agatoxin-IVA (Aga-IVA, 200 nm), and R-type blocker SNX-482 (100 nm) eliminated the response to K+ depolarization (50 mm for 5 s;arrows).