Fig. 1. Neonatal exposure to sevoflurane (Sevo) did not induce hypoperfusion of the brain. ( A ) Representative images of laser color Doppler for cerebral blood flow in a control mouse ( upper panel ) and in a sevoflurane exposed mouse ( lower panel ). The degree of perfusion is shown by the color code, with red representing high perfusion and blue representing lower perfusion. No different patterns of cerebral blood flow were observed between control and anesthetized mice throughout the 6-h exposure period. ( B ) Time course of cerebral blood flow measured by laser color Doppler during 6 h of 3% sevoflurane administration. The degree of perfusion is presented in arbitrary perfusion units. There was no difference between sevoflurane and control groups during the 6-h period (control, n = 3; 3% sevoflurane, n = 4). Scale bar : 5 mm.