Fig. 2. Microcirculatory blood flow in (  A ) healthy colon mucosa, (  B ) healthy colon serosa, (  C ) perianastomotic mucosa, and (  D ) perianastomotic serosa (%, means ± SD). Blood flow was set at 100% at baseline (t = 0 min). Group R-RL (restricted Ringer lactate) received 3 ml · kg⁻¹· h⁻¹Ringer lactate (RL); Group GD-RL (goal-directed RL) received 3 ml · kg⁻¹· h⁻¹RL + 250 ml of RL if Svo²was less than 60%; Group GD-C (goal-directed colloid) received 3 ml · kg⁻¹· h⁻¹RL + 250 ml of hydroxyethyl starch (HES; 130/0.4) if Svo²was < 60%. Significant differences in panels  A , B , and  D (  P < 0.05) for area under the curve (AUC): # = R-RL  vs. GD-RL, †= R-RL  vs. GD-C, $ = GD-RL  vs. GD-C. Significant differences in panels  A , B , and  D (  P < 0.05) for ANOVA for repeated measurements (Tukey  post hoc test): *= R-RL  vs. GD-RL, ≠= R-RL  vs. GD-C, §= GD-RL  vs. GD-C. No significant differences were detected in  C .