Time-dependent inhibition of transient outward K⁺ currents (I_to) by sevoflurane. Time course of the development of the inhibition by 0.35 mm (n = 7) and 0.7 mm (n = 8) sevoflurane after a depolarizing pulse to +60 mV from a holding potential of −40 mV. The reduction of I_to in the presence of sevoflurane is expressed as a proportion of the control current at any given time after the start of the depolarizing pulse.