Effects of sevoflurane (SEVO) on transient outward K⁺ currents (I_to) in rat ventricular myocytes. (A) Recordings of control, 0.7 mm SEVO, and recovery in a rat ventricular myocyte. (B) Current–voltage relations of I_to. Closedandopen circlesindicate the peak current of I_to at every potential in the control and in the presence of 0.7 mm SEVO. Squaresare the peak (closed) and plateau (open) currents after washout. Dotted linesalso indicate recovery. Trianglesare the plateau current levels at the end of the test pulses before (closed) and after (open) application of 0.7 mm SEVO. (C) Effect of 0.35 and 0.7 mm SEVO on the amplitude of peak I_to at +60 mV. *P< 0.05versuscontrol. Error barsindicate mean ± SEM.