Fig. 2. Voltage-dependent inhibition of Nav1.4 by inhaled anesthetics. Equipotent concentrations (1 minimum alveolar concentration [  MAC ]) of inhaled anesthetics differentially inhibited  I Nafrom a holding potential of –80 mV (  open bars ) or –120 mV (  filled bars ). The measured concentrations of halothane (  Halo ), isoflurane (  Iso ), sevoflurane (  Sevo ), enflurane (  Enf ), and desflurane (  Des ) were 0.42 ± 0.05 mm (1.2 MAC), 0.46 ± 0.03 mm (1.3 MAC), 0.44 ± 0.03 mm (1.0 MAC), 0.82 ± 0.04 mm (1.1 MAC), and 0.83 ± 0.03 mm (1.0 MAC), respectively, from a holding potential of –80 mV; they were 0.38 ± 0.05 mm (1.1 MAC), 0.41 ± 0.04 mm (1.1 MAC), 0.45 ± 0.05 mm (1.0 MAC), 0.80 ± 0.05 mm (1.1 MAC), and 0.83 ± 0.04 mm (1.0 MAC), respectively, from a holding potential of –120 mV. Data are expressed as mean ± SEM (n = 4–12). **  P < 0.01 by unpaired  t test. 

Fig. 2. Voltage-dependent inhibition of Nav1.4 by inhaled anesthetics. Equipotent concentrations (1 minimum alveolar concentration [  MAC ]) of inhaled anesthetics differentially inhibited  I Nafrom a holding potential of –80 mV (  open bars ) or –120 mV (  filled bars ). The measured concentrations of halothane (  Halo ), isoflurane (  Iso ), sevoflurane (  Sevo ), enflurane (  Enf ), and desflurane (  Des ) were 0.42 ± 0.05 mm (1.2 MAC), 0.46 ± 0.03 mm (1.3 MAC), 0.44 ± 0.03 mm (1.0 MAC), 0.82 ± 0.04 mm (1.1 MAC), and 0.83 ± 0.03 mm (1.0 MAC), respectively, from a holding potential of –80 mV; they were 0.38 ± 0.05 mm (1.1 MAC), 0.41 ± 0.04 mm (1.1 MAC), 0.45 ± 0.05 mm (1.0 MAC), 0.80 ± 0.05 mm (1.1 MAC), and 0.83 ± 0.04 mm (1.0 MAC), respectively, from a holding potential of –120 mV. Data are expressed as mean ± SEM (n = 4–12). **  P < 0.01 by unpaired  t test. 

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