Fig. 2. Myocardial infarct size expressed as a percentage of the left ventricular area at risk during control (CON) conditions, hyperglycemia (HYP), and simvastatin pretreatment (SIM) in the presence or absence of ischemic preconditioning (IPC) with or without  N -nitro-l-arginine methyl ester (L-N). Data are mean ± SEM. * Significantly (  P < 0.05) different from CON. † Significantly (  P < 0.05) different from HYP + IPC. ‡ Significantly (  P < 0.05) different from HYP + IPC + SIM.