Decimal fractional changes from baseline of the central compartment (V₁), obtained from changes in hemoglobin ([Hb]) and albumin concentrations,versustime for awake and isoflurane-anesthetized volunteers (n = 11), after infusion of 0.9% saline, 25 ml/kg body weight, during 20 min with start of infusion at 0 min. Values are mean ± SD.