Fig. 3. Expression of μ-opioid receptor (μOR), green fluorescent protein (GFP), and overlapping μOR immunoreactivity (-ir) with GFP in dorsal medial hind paw skin at 4 weeks after topical hind paw infection with SGAMOR, SGZ, or SGMOR. A –C show μOR-ir nerve terminals in the epidermis of the dorsal medial hind paw. D – F show GFP in the same section of tissue for which μOR-ir is shown in A – C . A and D show decreased μOR-ir in SGAMOR-infected skin. B and E show μOR-ir overlapped with GFP approximately half of the time in skin from SGZ-treated animals. C and F show GFP and μOR-ir colocalized in SGMOR-infected skin. Small arrows point out GFP and μOR-ir that do not overlap. Large arrows point out areas GFP and μOR-ir that are overlapping.