Fig. 6. Association between the response to a painful stimulus and the unmodified median frequency (MEF; A ), the median frequency modified for burst suppression only (MEFBS; B ), and the median frequency modified for burst suppression and spikes (mMEF; C ) for all rats during anesthesia with isoflurane. The rhombic dots show the individual values, the square dots show the mean, and the bars show the 95% confidence intervals of the means. The prediction probability Pkis a measure for the degree of association.