Fig. 3. The effects of sevoflurane (Sev) on field excitatory postsynaptic potentials (fEPSPs). (  A ) With amnestic concentrations of sevoflurane (<0.23 mm), there was no significant difference in fEPSP amplitude (  filled circle , n = 10) and duration from stimuli to fiber volley (FV;  open circle, n = 10). A linear curve fit was applied. (  B ) Clinical concentrations of sevoflurane (>0.23 mm) depressed fEPSP amplitude in a dose-dependent manner (  filled circle , n = 10). However, duration from stimuli to FV (  open circle , n = 10) did not change throughout the experiment. A linear curve fit was applied. (  C ) fEPSP responses (  upper ) were recorded from CA1 neurons. Bar graphs (  lower ) summarize the effects of sevoflurane on fEPSP amplitude. Sevoflurane (0.41 mm) depressed fEPSP amplitude markedly (n = 7, ***  P < 0.001). Bicuculline (BIC; 10 μm) did not reverse sevoflurane-induced fEPSP depression. Data are expressed as mean ± SD. NS = not significant.