Fig. 8. Dexmedetomidine (DMT) suppresses long-term potentiation in the presence of 2-(4,5-dihydroimidaz-2-yl)-quinoline (BU-224). ( A ) Sample traces recorded in the presence of BU-224 (10 μm) just before θ-burst stimulation (TBS) (a), immediately after TBS (b), or 60 min after TBS (c). ( B ) Sample traces recorded at the same time points in the presence of BU-224 (10 μm) and DMT (50 nm). ( C ) DMT attenuated long-term potentiation in the presence of BU-224 (n = 8 , P < 0.05 , filled circles ) compared with vehicle (n = 8 , open circles ). fEPSP = field excitatory postsynaptic potential.