Fig. 4. Dexmedetomidine (DMT) attenuates long-term potentiation in the presence of yohimbine (YOH) and WAY100635 (WAY). ( A ) Sample traces recorded in the presence of yohimbine (2 μm) and WAY100635 (1 μm) just before θ-burst stimulation (TBS) (a), immediately after TBS (b), or 60 min after TBS (c). ( B ) Sample traces recorded at the same time points in the presence of yohimbine (2 μm), WAY100635 (1 μm), and DMT (50 nm). ( C ) DMT suppressed long-term potentiation in the presence of yohimbine and WAY100635 (n = 8 , P < 0.05 , filled circles ) compared with vehicle (n = 8 , open circles ). fEPSP = field excitatory postsynaptic potential.