Figure 1. Proposed scheme for glutathione- and beta-lyase-dependent metabolism of compound A. 1 = 2-(Fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A); 2 = S-[2-(fluoromethoxy)-1,1,3,3,3-pentafluoropropyl]glutathione; 3 = S-[2-(fluoromethoxy)-1,3,3,3-tetrafluoro-1-propenyl]glutathione; 4 = S-[2-(fluoromethoxy)-1,1,3,3,3-pentafluoropropyl]-L-cysteine; 5 = S-[2-(fluoromethoxy)-1,3,3,3-tetrafluoro-1-propenyl]-L-cysteine; 6 = 2-(fluoromethoxy)-1,1,3,3,3-pentafluoropropanethiol; 7 = 2-(fluoromethoxy)-1,3,3,3-tetrafluoro-1-propenethiol; 8 = 2-(fluoromethoxy)-3,3,3-trifluorothiopropanoyl fluoride; 9 = 2-(fluoromethoxy)-3,3,3-trifluoropropanoic acid. GST = glutathione S-transferase; GS(H) = glutathione.