Fig. 4. The figure shows the dose of sevoflurane that causes a loss of the righting reflex in animals when they are given various intrathalamic doses of the nicotinic antagonist, mecamylamine before the determination. All animals had baseline loss of the righting reflex determinations made on a different day, and then four animals received the 25-μg dose of mecamylamine (in 0.5 μl saline) and four animals received the 50-μg dose in 0.5 μl ethanol. No significant effect on the dose of sevoflurane causing the loss of the righting reflex is apparent with either mecamylamine dose. Data are mean and SD.