Fig. 2. Factor VIII activity (%) and von Willebrand factor (vWF) concentration (%) nadirs within 2 h of the end of surgery for intent-to-treat (ITT) population and subset 3 (patients who received > 1,000 ml hydroxyethyl starch [HES]). Data are mean ± 95% confidence interval. Nadir factor VIII activity within 2 h of the end of surgery was significantly lower in the hetastarch group compared with the HES 130/0.4 group for ITT population and subset 3 (*  P = 0.0499 and  P = 0.0487, respectively). Nadir vWF concentration within 2 h of the end of surgery was significantly lower in the hetastarch group compared with the HES 130/0.4 group for subset 3 (*  P = 0.0078).