Fig. 2. Time course of hydroxyethyl starch (HES) 650/0.42/2.8 and HES 650/0.42/5.6 plasma concentration in g/l ( A ), plasma concentration in mm ( B ), weight averaged molecular weight (MWw) in kd ( C ), and number averaged molecular weight (MWn) in kd ( D ). In A and B , the absolute measured values are displayed by the symbols , whereas the lines represent the calculated values obtained by the used pharmacokinetic model. E shows the time course of the polydispersity index of the solutions. Concentrations and molecular weights were determined directly before infusion and 10, 20, 30, 40, 50, 60, 90, 120, 150, 270, 390, 510, and 630 min after. Results are shown as mean ± SD. * Solution effects of HES 650/0.42/2.8 versus HES 650/0.42/5.6 are determined by two-way analysis of variance.