Fig. 2. Early hyperemic reaction (EHR;  A ) and late hyperemic reaction (LHR;  B ) in the ischemic limb. The percent change in blood flow is shown for each subject at 15 and 30 min after test ischemia. Mean values and SDs are depicted next to the individual measurements. Note the marked reduction in LHR in the protocol without sevoflurane inhalation. In contrast, sevoflurane administration restored or even augmented hyperemic blood flow response. CTL = control protocol; NS = not significant; SEVO = sevoflurane protocol.