Fig. 6. Simulation of the relation between time (minutes) from 12:00 h, midazolam administration, population predicted midazolam concentration (  dashed line ), and population predicted COMFORT-Behavior score (COMFORT-B;  solid lines ).  A shows the simulation of 2 mg midazolam followed by a continuous infusion of 1 mg/h in a 10-month-old infant.  B shows the simulation of 1 mg midazolam followed by a continuous infusion of 0.5 mg/h in a 10- and a 15-month-old infant.  C represents the natural sleep pattern of a nonagitated infant. The  horizontal reference line ranges from the desired COMFORT-B 12 to 14.