Fig. 4. Time course of plasma coagulation parameters: antigenic von Willebrand factor (vWF) level ( A ), functional vWF activity ( B ), functional factor VIII (FVIII) activity ( C ), activated partial thromboplastin time (aPTT; D ), and prothrombin time (PT; E ). Parameters were determined before (baseline [BL]; arrow ) and 5, 20, 40, 60, 120, 240, 360, 480, and 1,200 min after the end of the colloid infusion. Results are shown as mean (SD). * Solution effect of carboxymethylated hydroxyethyl starch (CM-HES) versus hydroxyethyl starch (HES) (Psol CM-HES) and carboxymethyl starch (CMS) versus HES (Psol CMS) as determined by two-way analysis of variance.