Fig. 1. ( A ) Size distribution of total dorsal root ganglion neuronal population in control cultures and cultures treated with lidocaine at 40 mm. Dorsal root ganglion neurons were pooled from all spinal cord levels, and mean somal diameters were determined. Cell size ( x-axis ) is plotted against neuron number ( y-axis ). ( B ) Cell size categories of control cultures 48 h after seeding and cultures incubated with 40 mm lidocaine for 24 h, and control cultures at the same time point. Cell size categories ( x-axis ) are plotted against relative percentage of cells. ( C ) Distribution of isolectin B4 (IB4)- and calcitonin gene-related peptide (CGRP)–positive neuron populations in control cultures and cultures treated with 40 mm lidocaine for 24 h. Absolute neuron numbers in culture are printed in columns.