Fig. 5. Effects of low and high plasma concentrations of dexmedetomidine (Dex) on myocardial blood flow (MBF; A ) and coronary vascular resistance (CVR; B ), and the relations between the change in rate–pressure product (RPP) and MBF during the two infusion phases ( C ). Effects of dexmedetomidine on MBF and CVR are presented for individual subjects and the mean and their 95% confidence intervals of all subjects (presented as percent of baseline). Differences between means, their 95% confidence intervals, and the corresponding P values are from paired t tests. Changes in RPP between the Low and High Dex phases were associated with the corresponding changes in MBF. The regression line, r 2, and the corresponding P value are from a linear regression model. *** P < 0.001. NS = not significant ( P > 0.05).
