American Society of Anesthesiologists

$Fig. 4. Concentration–response surface for the effect of 0–10 μm propofol and 0–1.65 mm sevoflurane on the fractional change in the effective γ-aminobutyric acid concentration for 50% of maximal activation (GABA EC50) for α1β2γ2sGABAAreceptors expressed in HEK-293 cells. The horizontal axes represent anesthetic concentrations normalized to their EC50s for GABA EC50modulation (UA: sevoflurane; UB: propofol). The vertical axis represents the fractional effect on GABA EC50. The surface was fitted to the GABA EC50modulation data in table 3using a least squares algorithm written in Matlab.$

Fig. 4. Concentration–response surface for the effect of 0–10 μm propofol and 0–1.65 mm sevoflurane on the fractional change in the effective γ-aminobutyric acid concentration for 50% of maximal activation (GABA EC⁵⁰) for α¹β²γ^2sGABA^Areceptors expressed in HEK-293 cells. The horizontal axes represent anesthetic concentrations normalized to their EC⁵⁰s for GABA EC⁵⁰modulation (U^A: sevoflurane; U^B: propofol). The vertical axis represents the fractional effect on GABA EC⁵⁰. The surface was fitted to the GABA EC⁵⁰modulation data in table 3 using a least squares algorithm written in Matlab.

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