American Society of Anesthesiologists

$Fig. 1. Propofol, 2 μm, enhances currents activated by low (< 30 μm) concentrations of γ-aminobutyric acid (GABA). Whole cell responses to 0.3, 1, 3, 10, 30, 100, 300, and 1,000 μm GABA in the absence (first eight responses) and presence (last eight responses) of 2 μm propofol. Whole cell recordings were made from HEK-293 cells voltage clamped at −60 mV expressing α1β2γ2sGABAAreceptor subunits. The filled bar above the current traces denotes the period of propofol application, and the open bars denote the period of GABA application. The application of 2 μm propofol shifted the EC50for GABA from 4.8 to 2.6 μm, a fractional shift of 0.54.$

Fig. 1. Propofol, 2 μm, enhances currents activated by low (< 30 μm) concentrations of γ-aminobutyric acid (GABA). Whole cell responses to 0.3, 1, 3, 10, 30, 100, 300, and 1,000 μm GABA in the absence (first eight responses) and presence (last eight responses) of 2 μm propofol. Whole cell recordings were made from HEK-293 cells voltage clamped at −60 mV expressing α¹β²γ^2sGABA^Areceptor subunits. The filled bar above the current traces denotes the period of propofol application, and the open bars denote the period of GABA application. The application of 2 μm propofol shifted the EC⁵⁰for GABA from 4.8 to 2.6 μm, a fractional shift of 0.54.

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