Fig. 4. Effects of sevoflurane on the cloned human cardiac transient outward potassium channel, Kv4.3. (  A ) Whole cell Kv4.3 channel currents were elicited by 300-ms depolarizing pulses to +10 mV from a holding potential of −90 mV every 5 s. Current was measured in picoamperes. The effects of 0.3 and 3 mm sevoflurane on Kv4.3 are shown. (  B ) Dose–response relation for sevoflurane inhibition of peak Kv4.3 channel currents. Maximal inhibition of Kv4.3 by sevoflurane measured 28% at a concentration of 3 mm.  Error bars denote SEM (n = 8). (  C ) Sevoflurane speeds Kv4.3 current decay. The Kv4.3 current decay time constant (Tau) was fit to a single exponential function and measured 16.3 ms before addition of drug. Sevoflurane accelerated the rate of Kv4.3 current decay at concentrations of 0.3 mm and higher. * Significantly different compared with control values (  P < 0.05).  Error bars denote SEM.