Fig. 2. Simulated population propofol concentrations (line ) versus observed concentrations ( solid circles ) in an infant aged 10 months and weighing 10 kg, after continuous infusion of 18, 24, 30, and eventually up to 42 mg/h. The simulations were based on the current study ( solid black line ) and published pharmacokinetic models in ventilated children after cardiac surgery ( dashed line ) 3,( dashed and dotted line ) 16,and during anesthesia ( solid gray line ). 17